This content does not have an Arabic version. See more conditions. Drugs and Supplements Probenecid Oral Route. Products and services. Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Sign up now. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. It usually is taken two times a day when prescribed for chronic gout or gouty arthritis and four times a day when prescribed with antibiotics to make them more effective.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take probenecid exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Probenecid may increase the frequency of gout attacks during the first 6 to 12 months that you take it, although it will eventually prevent them.
Another drug, such as colchicine, may be prescribed to decrease this effect. Drink at least six to eight full glasses of water a day while taking probenecid to prevent kidney stones, unless directed to do otherwise by your doctor.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
When the uric acid is under control, the dose may be changed. Probenecid can be taken with or without food. You should drink plenty of water while taking probenecid.
This will help flush the uric acid from your kidneys as the medication starts working. This is especially important if:.
Your healthcare professional may do blood tests to check your liver function while you are taking Probenecid.
The most common side effects of Probenecid are liver problems, nausea, gout flares, joint pain, and rash. Contact your prescriber if any of these side effects occur. When you are taking Probenecid, it is very important that your doctors know if you are taking any other medicine. This includes prescription and non-prescription medicines as well as birth control pills, vitamins, and herbal supplements.
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