Some studies show an advantage to glucosamine sulfate; others to glucosamine hydrochloride. One study that compared the two glucosamine forms head to head found no real difference between them. Mayo Clinic researchers agree, saying that evidence supports trying glucosamine sulfate — not hydrochloride — with or without chondroitin sulfate for knee OA. Glucosamine and chondroitin are considered safe, with no serious side effects reported in studies. However, these supplements can interact with blood thinners like warfarin Coumadin.
They might also affect blood sugar levels, and one small study found they raise eye pressure, which could increase the risk for glaucoma. If you have diabetes or glaucoma, you may need to avoid these supplements, or have your doctor monitor your blood sugar levels and eye pressure more closely while you take them.
That means that there isn't strong evidence that benefits outweigh risk, but the supplement could be helpful for people with OA. Also, be patient. Get involved with the arthritis community. Every gift to the Arthritis Foundation will help people with arthritis across the U.
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Currently this program is for the adult arthritis community. If you have any questions about this supplement, please ask your physician. Glucosamine sulfate and chondroitin sulfate are naturally occurring substances found in the connective tissues of the body, including the cartilage that covers the ends of bones in the joints.
Glucosamine sulfate functions are the primary building block for proteoglycans, large molecules in cartilage that give it viscoelastic buffering properties. When taken orally, glucosamine sulfate is absorbed readily into the system and can be traced to cartilage as soon as four hours after consumption. Similar to non-steroidal anti-inflammatory drugs, glucosamine sulfate has been shown to have unique anti-inflammatory effects.
Additionally, in some laboratory tests, the glucosamine supplement demonstrated a protective effect on the cartilage as well. These studies suggest that glucosamine sulfate may inhibit the breakdown of cartilage associated with osteoarthritis and may have the potential to help build-up cartilage. Glucosamine hydrochloride, another form of glucosamine, is available as a nutritional supplement and is considered to be as effective as the sulfate form although there are fewer completed studies to review.
This hydrochloride form of glucosamine is more available for absorption into the body; therefore, a smaller dose delivers an equivalent amount in the system. Chondroitin sulfate is a larger molecule also found in cartilage. Chondroitin sulfate has been studied much less extensively, but early results show that it also seems to work as an anti-inflammatory and reduces pain. Some laboratory studies suggest that chondroitin sulfate may slow cartilage breakdown associated with osteoarthritis and even stimulate cartilage growth.
Many patients who suffer from osteoarthritis may benefit from the positive effects of taking this supplement. The painful symptoms of osteoarthritis may appear when cartilage becomes worn, and exposed bones begin to rub together. Conventional medicine does not yet have a proven treatment to stop or slow the progression of osteoarthritis. Traditional medical treatment includes drug therapy to control the pain associated with osteoarthritis. Oral use of glucosamine sulfate can cause:.
Because glucosamine products might be derived from the shells of shellfish, there is concern that the supplement could cause an allergic reaction in people with shellfish allergies. There's some concern that glucosamine might raise eye pressure. If you have glaucoma, talk to your doctor before taking glucosamine supplements.
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